Source = ETB Travel News: Megan Tran The first of three new films by the South Australian Tourism Commission (SATC) aimed at encouraging visitors to Adelaide during the Cricket World Cup premiered in New Delhi today.The film stars Indian cricketer Ajay Jadeja and encourages Indians to visit South Australia when it hosts the opening game of the ICC Cricket World Cup in February 2015.Deputy Premier John Rau said the India versus Pakistan game is a drawcard for the state, providing tourism opportunities.“The film aims to uncover the real South Australia. We wanted to capture the experiences of real people and this film does that in a creative way.”Mr Rau said the first film shows South Australia through the eyes of Ajay Jadeja and his son on their recent visit and features attractions such as, the Barossa, Kangaroo Island and the Adelaide Hills.The films were conceptualised and commissioned by SATC as part its India Strategy 2020, directed by Indian film maker Deepti Chawla and produced by Daydreamer Pictures. The aim was to create content that Indian visitors could relate to and identify with.“India is an important market for South Australia and these films are aimed at creating awareness and appeal for the State. Mr Rau said.“There is huge potential to showcase our state through the online medium and these films are designed to tap into that potential.”
Report Finds Mortgage Concerns Are One of the Top Financial Reasons Americans Lose Sleep More Americans are sleeping better at night knowing that the economy is recovering. Those Americans that are losing sleep over financial stress is declining in the U.S., according to a new CreditCards.com poll.The national poll, commissioned by CreditCards.com, also found that 62 percent of adult Americans are losing sleep over at least one financial problem. This is 7 percentage points lower than the amount in June 2009, the last time this poll was conducted, but higher than 56 percent in 2007.One of the top insomnia-inducing issues that worries many Americans is how they will pay their mortgage and monthly rent bills, the poll determined. Twenty-seven percent indicated that home and rent payments block sleep at night.“Many Americans are still struggling financially, even as the economy rebounds,” said Matt Schulz, senior industry analyst for CreditCards.com. “Twenty-seven percent of Americans are losing sleep over mortgage or rent payments—about the same number as in 2009, in the throes of the Great Recession when we last did the survey. And 1 in 3 Americans between the ages of 18 and 49 are losing sleep over paying their rent or mortgage.”According to the poll participants, the most common financial worry is saving enough for retirement. Two-in-five Americans noted that stress about retirement keeps them awake at night at least occasionally. The next big concern is educational expenses, which troubles young adults the most.“Ultimately, it’s about income. They say money can’t buy you love or happiness, but according to our survey, it can sure as heck buy you a better night’s sleep. Those making $75,000 or more per year were the least likely to be losing sleep, while those making less than $30,000 per year were the most likely.”CreditCards.com found that 40 percent of poll respondents are restless at night because of retirement savings. This anxiety cause the most amount of stress, especially among those adults who are approaching retirement age. Educational expenses seem to another burden among American that causes wakefulness thought the night. Approximately 31 percent of participants pointed out that they are deeply concerned with their ability to pay their own or someone else’s educational expenses.Americans are also worried about health care or insurance bills and how they will manage to pay these necessary expenditures. The poll found that 29 percent of people lose sleep over these financial stressors, a 6 percent decrease since 2009. Americans place credit card debt at the bottom of their list of worries, with 21 percent saying that this troubles them at night.”I think people are better off today than they were six years ago,” said James Chessen, chief economist with the American Bankers Association (ABA). “They are more secure in their jobs, their incomes are a little better, housing values are improving and they’ve managed their debt. There are still a lot of challenges, but overall people are in better positions than they have been since the recession.”CreditCards.com advises those Americans who are losing sleep at night due to financial woes to review their finances thoroughly, spend less, start an emergency fund, and come up with a budget.”I’m guessing someone who is really worrying does not have the basics covered,” said Edward Tonini, director of education at Alliance Credit Counseling. “For a lot of us, the unknown can really create the most anxiety. Take little steps and focus your energy on them and feel some sense of relief that at least you are making progress. It might take longer than you would like it to take, but realistically you have to work within your budget.”Click here to view the complete CreditCards.com poll. June 25, 2015 498 Views Share CreditCards.com Economy Financial Stress Mortgage Payment Rent Payment 2015-06-25 Staff Writer in Daily Dose, Data, Headlines, News, Uncategorized
August 8, 1997Casting a Hydrocal panel for the Soleri wing of the Tucson Cancer Center.
August 2, 2002 in camp is being prepared forthe installation of a new acrylic cover. Agriculture employee Brett Snyder is loosening thewooden support beams to remove the old membrane that is covering thedrying chambers. [Photo & Text: SA] The construction crewand helpers from various departments are in place and the new cover isslowly unrolled. [Photo & Text: SA] The crew startedright after morning meeting to avoid the temperamental winds whichusually start around noon this time a year. But the wind started early,just couldn’t resist playing with this. [Photo & Text: SA] The crew had theirhands full. [Photo & Text: SA] The cover is inplace. Now it is just a matter of securing it. [Photo & Text: SA] The ends have to berolled in and everyone is making an effort to stretch the plasticmembrane evenly. [Photo & Text: SA] manager Adam Nordfors [with red bandana]is drilling the wooden support beams back into place. [Photo & Text:SA] TheGreenhouse is back on line. [Photo & Text: SA]
Swiss service provider Sunrise reported a 20.4% year-on-year increase in TV customers at the end of the second quarter.Reporting its Q2 results, the operator said it added 24,200 TV subscribers year-on-year, taking its total to 147,200 customers.“The solid TV customer growth reflects the advantages of Sunrise Home over other providers. Sunrise Home customers can put together their own packages consisting of landline service, internet and Sunrise Smart TV,” said the company.Sunrise also grew its internet customer base by 7.3% year-on-year to 357,500, and said that its internet and TV base “developed favourably” due to attractive tariffs and the competitive Sunrise Smart TV product.Despite this, the company reported revenues of CHF472 million (€434 million), down 3.2% year-on-year, while Net income came in at CHF 10 million, down from CHF 14 million a year earlier.“While having joined Sunrise only in the mid- of the reported quarter, I am pleased to see that the revenue decrease halved compared to Q1,” said Sunrise CEO, Olaf Swantee.“As a solid basis for a strong market position, the company invested in an improved network, customer service and in innovative convergent products for residential and business customers.“Nevertheless there is more to be done in these respective areas and I look forward to further strengthen our position as the leading challenger”.
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March 3, 2017 David Schonthal and Brooke Vuckovic Learn how to successfully navigate family business dynamics and build businesses that excel. Opinions expressed by Entrepreneur contributors are their own. –shares Free Webinar | July 31: Secrets to Running a Successful Family Business Emotional Intelligence The Uber CEO’s public angst about berating a driver and confronting sexual harassment allegations reveals the need to grow in personal skills as well as business skills. Guest Writer Travis Kalanick’s ‘Profound Apology’ Is a Cautionary Lesson for Young Founders Register Now » The “profound apology” issued by Uber founder and CEO Travis Kalanick that he must “fundamentally change as a leader and grow up,” in response to a video showing him berating a driver that went viral, underscores how the pressures of a high-growth startup can undermine leadership development when and where it’s needed most.In his apology, posted on the Uber site, Kalanick admitted, “This is the first time I’ve been willing to admit that I need leadership help and I intend to get it.” For Kalanick, who has also faced criticism for the culture at his company after sexual harassment allegations went public in a blog by a former employee, this is a crucial admission. The serial entrepreneur, who founded file sharing startup Red Swoosh in his early 20s and Uber in his early 30s, shows the importance of entrepreneurs developing holistically — vertically into self-awareness and self-management, as well as horizontally across the skills needed to run a business.Kalanick’s statement that, “My job as your leader is to lead…and that starts with behaving in a way that makes us all proud,” is also a cautionary tale for entrepreneurs who don’t put sufficient emphasis on personal and leadership development.As our work with young entrepreneurs shows, capturing the investors’ interest takes more than just a great idea or even good results. Founders who exhibit self-awareness, leadership ability and agility, and who can grow along with their company, will be more likely to go the distance. The intensity and pace of launching and scaling a high-growth startup are so great, young founders, in particular, must pay attention to the amplifying effects of speed on their leadership. Entrepreneurs who develop holistically establish the foundation for building the necessary confidence to manage complex relationships, competing priorities, and fast-paced decisions.While it’s common for young entrepreneurs to have mentors, many of whom are experienced entrepreneurs and investors, much of the feedback from these sources is focused on the functional elements of business-building (product development, marketing, design, finance etc.). What’s far less common is thoughtful guidance on how these founders successfully evolve into leaders — and how their “executive DNA” may positively or negatively impact the success of their early ventures.No matter how good the idea or convincing the business model, a startup rises and falls on the leader’s capacity to develop and grow alongside the business. There are three dimensions of awareness that deepen a young founders EQ.Related: Uber CEO Travis Kalanick Says He Needs to ‘Grow Up’ After Video of Argument With a Driver ReleasedAwareness One: Strengths, Weaknesses and DerailersWithout self-awareness of one’s strengths and weaknesses, it becomes difficult if not impossible to build a team with complementary skills and expertise. To gain this awareness, young founders need to reflect on the key strengths essential to the team and to the success of the business. They also should know when to rely on others’ strengths and perspectives.The temptation among many organizations, including startups, is for leaders to gravitate toward those who are “same as me.” But as research has found, homogeneity can stifle creativity and hold back the organization. A team that is diverse in terms of gender, race and ethnicity, as well as experience, thinking styles, and background is better equipped to tackle problems and bring to bear insights that create breakthrough innovations. One cannot do this without a high degree of self-awareness.Related: 3 Lessons Every CEO Can Learn From Travis Kalanick’s Emotional Meeting With Uber’s Female EngineersAwareness Two: Orientation to ConflictWithout understanding their orientation to conflict, founders will struggle to manage difficult or disappointing conversations. Key reflections here are how they manage interpersonal conflict with others, and how they manage operational conflicts among competing priorities and commitments.For founding leaders of startups, there’s no avoiding bad news, disappointing results, tough feedback, and making hard decisions that leave others unhappy. A “softer” version of conflict comes into play internally as the young founder struggles with when and how to say no. The leader who learns the art of a “positive no” is more apt to maintain a laser focus on priorities in the business and in their personal productivity. They will also avoid the classic trap of becoming over-committed and yielding anemic results across the board; unable to prioritize and delegate authority to others, particularly as the company grows.Related: Uber CEO Travis Kalanick Launches Investigation Into Sexual Harassment ClaimsAwareness Three: Your Values and PurposeThough last on this list, knowing one’s values is perhaps the most important awareness founders must have, as their personal values establish their startup’s culture. Key questions here are what do you stand for, and why does this venture exist?Much like the process of product development, developing one’s identity as a leader is an iterative, others-focused process that involves trial and error. However, the leader’s identity and toolkit are often developed at warp speed as their business begins to scale. Without a clear sense of one’s values and purpose, founders are less likely to project the optimism and confidence demanded of them, and are more likely to become over-invested in their image, less open to learning, and less clear about their goals.In the corporate world, leaders typically gain these three dimensions of awareness as they build a sense of self over time, through training, experience, and classic management relationships. But high-growth startups are a “heat inducing laboratory” in which young founders are thrust into high-stakes leadership roles quickly, and sometimes prematurely, as the business scales and the team grows. This makes foundational coaching and interpersonal development more important early on, even before a startup is launched. In this respect, founder-leader fit is a close second to product-market fit.For many young founders, the first taste of executive leadership accompanies the excitement and pressure of a startup launch. For those who grow both horizontally across business functions and vertically in leadership maturity and skill, success may be more likely, and certainly more satisfying. Chances are, they’ll never have to apologize publicly for a lack of leadership maturity as Kalanick just did. 6 min read Faculty at Kellogg School of Management Next Article Image credit: Bloomberg | Getty Images Add to Queue
Integration Allows More Brands and Media Companies Access to Cross-Device Analytics as They Continue to In-House Their Programmatic StrategiesTapad, a global leader in digital identity resolution announced that it has added Beeswax, the industry’s first extensible programmatic buying platform, to its ever-growing roster of media buying partners. Beeswax is unique in that it offers Bidder-as-a-Service™ capabilities, which when partnered with The Tapad Graph, allows sophisticated buyers to make the most out of their programmatic spend.“Digital identity resolution is key to enabling independent DSP providers to be more efficient in digital marketing,” said Chris Feo, SVP of Global Data Licensing and Strategic Partnerships at Tapad. “By partnering with Beeswax, we are able to extend our cross-device capabilities to Beeswax’s client base, allowing their customers to better connect with target audiences at scale.”Marketing Technology News: Anexinet Continues Growth Under New OwnershipThrough the partnership, Beeswax’s brand and media customers in the US will have the option to access The Tapad Graph’s privacy-safe digital identity resolution insights via the Beeswax platform. Identity resolution provides clients with a holistic view of the consumer journey across devices, which in turn, enables marketers to streamline messaging and to increase campaign ROI through targeting analytics and attribution.Marketing Technology News: New Competitive Report by BIA Advisory Services Shows Similarities and Differences Among Leading Call Tracking Platforms“After evaluating many of the solutions in the market, we’re thrilled to have landed on Tapad as our first identity partner and cross-device graph,” said Ari Paparo, Co-Founder & CEO at Beeswax. “Brands and media companies that use our platform will now have expanded digital identity resolution capabilities, allowing them to make smarter bidding decisions, and maximize their programmatic spend.”Marketing Technology News: Button Raises $30 Million in Series C Funding to Build the Future of Mobile Commerce Tapad Partners with Programmatic Buying Platform, Beeswax, to Extend Identity Resolution PRNewswireJuly 5, 2019, 3:54 pmJuly 5, 2019 BeeswaxBidder-as-a-ServiceMarketing TechnologyNewsprogrammatic buying platformtapad Previous ArticleCustomer Experience Transformation Will Attract 23% of 1.68 Billion Dollars Invested in Digitalization in 2019Next ArticleConverge Technology Solutions Acquires Nordisk Systems, Inc.
Source:https://www.hopkinsmedicine.org/news/newsroom/news-releases/decrease-in-specific-gene-silencing-molecules-linked-with-pediatric-brain-tumors Reviewed by Alina Shrourou, B.Sc. (Editor)Nov 12 2018Experimenting with lab-grown brain cancer cells, Johns Hopkins Medicine researchers have added to evidence that a shortage of specific tiny molecules that silence certain genes is linked to the development and growth of pediatric brain tumors known as low-grade gliomas.A report of the findings was published this fall 2018 in Scientific Reports, and supports the idea of increasing levels of microRNAs as a potential means of treating these tumors.An estimated 1,600 cases of pediatric low-grade gliomas (PLGGs) are diagnosed annually in the United States, and the vast majority of these slow-growing tumors are treatable and curable mainly by surgical removal, although in some cases surgery has the potential to damage critical nearby brain tissue, depending on tumor location. Unlike high-grade glioblastomas such as the one that took the life of Arizona Senator John McCain, PLGGs mostly affect school-age children and young adults.”It has long been known that microRNAs play a role in controlling various tumor properties such as growth,” says Fausto Rodriguez, M.D., associate professor of pathology at the Johns Hopkins University School of Medicine and the study’s senior author.”Our findings identified a subset of microRNAs that, in sufficient quantity, seem to decrease the growth and invasion of cancerous cells in pediatric low-grade gliomas.”MicroRNAs are tiny molecules that, in ways similar to how an orchestra conductor controls the flow of each instrument group, command the expression of entire gene networks that make proteins by essentially silencing them, and are responsible for regulating biological processes such as nutrient intake, cell growth and cell death. Altered levels of specific microRNAs can disrupt entire biological pathways just as a misguided section of an orchestra can unsettle an entire score.”One microRNA can target multiple genes and have a profound effect on cell processes, and the alterations are dynamic,” notes Rodriguez, who says PLGGs are good candidates for analyzing microRNA types and levels because genetically PLGGs are stable compared with other tumors. That makes it relatively easier, he says, to identify any relevant genetic abnormalities and potential targets for therapy.Related StoriesRepurposing a heart drug could increase survival rate of children with ependymomaNanoparticles used to deliver CRISPR gene editing tools into the cellNew therapy shows promise in preventing brain damage after traumatic brain injuryFor the new study, the researchers first analyzed previously gathered microRNA subtype data in two studies. They examined tumors from 125 patients with low-grade gliomas for levels of a specific microRNA, known as miR-125b, using chromogenic in situ hybridization (CISH), a technique that is applicable to routinely processed tissue in pathology and allows for identification of specific microRNAs in the cells of interest. Levels of this microRNA were lower in 43 pilocytic astrocytomas (the most common subtype of PLGG) when compared with 24 diffuse astrocytomas and normal brain tissues.Rodriguez and the research team next looked at eight cancerous cell lines derived from brain (glial) tumors in children for levels of microRNA 125b-p using a method that can rapidly make thousands to millions of copies of a genetic sequence for easier analysis of how much of a gene is expressed. Although levels of microRNA 125b-p varied across the lab-grown cell lines, they were significantly and uniformly lower in cancerous cell lines than noncancerous cell lines, Rodriguez reports.In further experiments designed to identify the role of these microRNAs in cell growth, the investigators increased levels of miR-125b in cancerous cell lines by introducing a DNA segment in the tumor cells using specific viruses, and saw a decrease in cell division and growth. To check whether cell death contributed to this decrease in cell growth, Rodriguez stained cells containing high levels of microRNA 125b and noted cell death in all cell lines, suggesting that increasing levels of microRNA 125b can stop the growth of PLGG.”These findings are an example of where advances in precision medicine might take us, and show how, someday, increasing levels of specific genes and microRNAs might be a targeted treatment for PLGGs,” says Rodriguez.
Dementia, particularly Alzheimer’s disease, is much more prevalent in older adults. As the number of older Oklahomans increases, this disease will become more common. We don’t want people with Alzheimer’s and their caregivers to become isolated. We want communities and healthcare systems that are friendly to people with cognitive impairment and memory loss. We want people to thrive as long as they can, as best they can, with the support that they need.”Lee Jennings, M.D., OU College of Medicine Reviewed by Kate Anderton, B.Sc. (Editor)Jul 3 2019The University of Oklahoma Health Sciences Center, working with partners across the state, has been awarded a $3.75 million federal grant to enhance the care and support of a growing group of Oklahomans – those who suffer from memory loss, Alzheimer’s disease and other types of dementia.According to the Alzheimer’s Association, 65,000 Oklahomans currently live with Alzheimer’s, and that number is expected to grow. An especially cruel disease with heartbreaking cognitive decline and no cure, Alzheimer’s requires a circle of support so that people with the disease can live as well as possible for as long as possible.The program established by the grant will focus on two overarching objectives: educating the current and future workforce to better care for people with dementia, and creating dementia-friendly health systems. Unfortunately, Oklahoma ranks near the bottom in several quality of life and health rankings for older adults. Lee Jennings, M.D., a geriatrician with the OU College of Medicine who is leading the grant, said she hopes the upcoming efforts will improve those numbers. The structure of the program is uniquely opposite of most academic grants. Rather than working solely with physicians and students on campus, the program will engage primary care clinics around the state, direct-care providers such as nursing home staff, organizations like the Alzheimer’s Association, and family members and caregivers of people with dementia.Most of the medical care for patients with dementia is provided by primary care clinics, but that only accounts for a short medical visit. That means families and other caregivers are taking care of loved ones the majority of the time. And because Oklahoma is largely a rural state with not enough primary care physicians, the need is great to increase support and knowledge for everyone helping a person with dementia.Hudson OU College of Public Health department chair Thomas Teasdale, who holds a doctorate in public health, is co-leading the program with Jennings. Through an existing partnership with the Oklahoma State Department of Health, Teasdale already works with the state’s 300-plus nursing homes, where 70 percent of residents live with some type of dementia. The grant also will allow him to enhance dementia care education for new audiences, including community health workers, in partnership with the Oklahoma City-County Health Department. Another partner agency, the Oklahoma Foundation for Medical Quality, will provide quality improvement consulting as the program evolves.Related StoriesDementia patients hospitalized and involved in transitional care at higher ratesA program of therapy and coping strategies works long-term for family dementia carersUse of statins linked to reduction of mortality risk in dementia patientsJennings and her team also will work with OKPRN, the Oklahoma Practice-Based Research/Resource Network, a large group of physicians who conduct ongoing research to improve the care they provide. In addition, the grant will allow OU dementia specialists to provide tele-consultations for rural physicians who might need help treating patients with complications.”We want to offer rural providers the expertise in our university setting. They may need new strategies for managing a patient’s neuropsychiatric symptoms or treating difficult diagnoses related to dementia,” Jennings said.The grant’s second objective — to create dementia-friendly health systems – covers everything from the physical layout of a clinic to the community resources that are available for people and their caregivers. Clinics can improve their environments by ensuring signs are understandable, exam tables are easy to use for older adults, and sensory aids like hearing amplifiers and large-print materials are available.A dementia-friendly practice also means both clinical providers and staff can connect patients and families with community resources where they live. Support groups, for both caregivers and the person living with dementia, are often crucial in helping people cope. They also can help reduce the stigma that is still associated with the disease.”We want to let people know that there are resources, and we don’t want caregivers to feel stigmatized,” Jennings said. “It can be isolating if caregivers don’t feel like they can go out into the community with their loved one. We want to help people live with dignity and be as independent as possible while they age with this disease.”The effort also extends to Oklahoma’s Native American tribes. The Choctaw Nation in particular is working not only within its own geriatric clinics, but beyond the healthcare setting to transportation access for people with dementia.”This grant and program would not be possible without our many community partners,” Jennings said. “We are putting these federal dollars to use in our communities throughout Oklahoma to improve the health and quality of life of people with memory loss, Alzheimer’s disease and other types of dementia.”This federal grant was awarded by the U.S. Department of Health and Human Services under the award number 1 U1QHP330820100. Source:University of Oklahoma
COMMENT COMMENTS Election Commission of India Finance Minister Arun Jaitley has said the exit polls broadly convey the Lok Sabha poll results, which will be announced on May 23. Jaitley wrote in his blog that if the results of the exit polls and final results are in the same direction, the Opposition’s “fake issue” of the EVMs would also lose its “non-existent rationale.”The Finance Minister said exit polls are based on personal interviews and EVMs have no role in it. “If the exit polls are read along with the 2014 election results, it would be clear that a huge maturing of Indian democracy is taking place. The electorate keeps national interest paramount before exercising a choice on whom to vote for. When well-meaning people with similar ideas vote in the same direction, it leads to the making of a wave,” he wrote.On ‘dynastic parties’He said “dynastic parties, caste parties and the obstructionists Left” received a setback in 2014 and this trend will be reiterated, “loud and clear”, in 2019. “Coalition of rivals is an untenable alliance and the voters are no longer willing to trust them. Political analysts are confused but the voters are clear. They don’t elect hung Parliament where ugly and untenable coalitions have a role to play,” he said.He claimed that the arithmetic of caste coalitions has lost to the chemistry on the ground created for the front-runner in the elections. “This chemistry is in form of catching the imagination of the people on issues of national interest,” he said and added that the Prime Minister’s style of rising above caste and concentrating on performance-related issues received far more acceptability from the electorate.“I re-assert my earlier hypothesis — in the Congress, the first family is no longer an asset but an albatross around neck of the Party. Without the family, they don’t get the crowd, with it they don’t get the votes,” he said. ‘A new India’Jaitley said many politicians believe the ultimate wisdom lies only with them. “They are, thus, unwilling for any radical solutions. The evolving ‘new India’ will accept structured parties with talent and ideological clarity. If, however, the political parties are unwilling to get the message of 2014 and the possibly of 2019, then alienation from the electorate will only widen,” he said. SHARE SHARE EMAIL Arun Jaitley (file photo). – REUTERS May 20, 2019 SHARE national elections Published on